In order to evaluate the effects of the extracorporeal shock waves (EDAP`LT 01) on the gallblad-
der and it´s efficacy on experimentally induced cholelithiasis in the adult mongrel dogs, a series of
experiment were conducted in this study and the results were summarized as follows:
1. In-virto studies, it was observed that gallstones of different chemical composition can be fragmented completely by shock waves when their size was measured less than 10mm and fragmented partially above 16mm in size.
2. No significant ECG change in the canine heart during the shock wave treatment were observed.
3. Transient elevation of hepatic (SGOT, ALP) and pancreatic (amylase) enzymes were noted with 72,000 pulses 900 bar shock waves. However, no abnormal elevation of enzymes were-observed with 30,000 pulses 900 bar shock waves. Slight elevation of ALP was observed in the dogs with experimentally induced cholelithiasis and thought to be due to biliary tract obstruction by fragmented stones.
4. No significant, tissue injury were observed in histologic examination of gallbladder and neighbouring organs (liver, pancreas and duodenum), nor was there a significant serious lesion in the high energy burden induced by either a 30,000 or 72,000 pulses in different deliveried shock waves.
5. In dogs with implanted stones, effective fragmentation of the stones were achieved without any significant complication. The problem of residual stones in the gallbladder after the shock wave treatment may be considered.
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